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Changing genes to treat HIV The next generation of therapy to treat HIV, and perhaps eventually to cure it, is likely to involve changing the genes in your body. A small study in just six patients discussed in Boston at the 18th Conference on Retroviruses and Opportunistic Infections opened the door to those possibilities. The clinical trial by San HIV physician Lalezari took CD4 T-cells from each patient; knocked out a section of DNA that codes for the CCR5 cell receptor; grew those mutated cells to large -; and then put 30 million of them back into the patient. It used zinc finger technology developed by the Bay Area biotech company Sangamo to create the genetic deletion. The primary goal of a phase 1 trial is safety, and this procedure passed with flying colors. The bonus was that it also appeared to robustly increase the number of CD4 cells in the patients. And there is no sign that HIV is able to infect them. Lalezari said there was "a significant engraftment and expansion of the cells and a fold increase over what would have been predicted." Those changes seem to be lasting as 67 percent of the CD4 cells sampled in the blood months later carried the modified DNA. It is "probably as good as we could have hoped for in this population." The data is preliminary and the study is ongoing, with a multitude of questions that must be answered. They include: How are the modified CD4 cells going to last? Do they have the same antimicrobial activity as unmodified cells? And, they reappear as quickly as before? FULL STORY:
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